Pediatric occult hepatitis 228 reported and still without cause

In just under a month, 228 cases of pediatric acute hepatitis that remain of unknown origin were reported to global health authorities, and more than 50 cases are currently under investigation. A frightening escalation due to speed, gravity, global reach and above all because the cause remains a mystery. It was Tarik Yasarevich of the World Health Organization who assessed the situation. “Since the first report that arrived from the UK on 5 April until 1 May 2022, there are now at least 228 probable cases reported from 20 countries and more than 50 cases are now under investigation. So, we now have cases reported from Five regions of the country.“WHO, Eastern Mediterranean, Europe, Pan-American and even Southeast Asia and Western Pacific,” he explained.

In the past few hours, a case was also reported in Argentina, an eight-year-old boy who was admitted to the Children’s Hospital of Rosario. So far, one death worldwide has been confirmed from this disease, while four more deaths are being investigated. 18 minors who underwent a liver transplant.

What worries us is the difficulty in determining the origin of the pathology. Tests for viruses known to cause disease gave negative results, and the association with Covid was excluded, and the relationship with a specific region or food was also excluded because the cases have dislocations that do not allow printing of this type. In short, a puzzle.

At the moment – reads the latest document from the Institute of Health (April 29, so) – None of the theories that have been formulated about the origin have been confirmed by scientific evidence. Moreover, every year in Italy, as in other countries, a certain number of idiopathic hepatitis occurs, and analyzes are carried out to determine whether there is really an excess. Preliminary hypotheses from the UK investigation team suggested infectious etiology or possible exposure to toxic substances. Detailed information collected through a questionnaire regarding food, drink and personal habits of the cases did not reveal common exposures. Toxicological investigations are ongoing, but the infectious etiology appears to depend on the epidemiological picture. Microbiological examinations excluded hepatitis A, B, C, D and E viruses in all cases. Based on current investigations — the Centers for Disease Control and Prevention wrote in its risk assessment on April 28 — the most plausible hypothesis currently is that a cofactor affecting children with adenovirus infection, which may be mild under normal circumstances, leads to infection More dangerous or immune. mediated liver injury; Other reasons are still under investigation and have not been ruled out.

The focus is on observation. For two reasons: because timely diagnosis increases the chances of recovery and recovery and obtaining a comprehensive picture of the condition. In recent weeks, the warning “Don’t do like Covid” – that is, don’t underestimate the disease – has reverberated from one end of the globe to the other.

In Italy, due to the increase in cases of acute hepatitis in children (by decree of April 27), a crisis unit was created, which includes the Ministry of Health, the Higher Institute of Health, the Regions, Agneas (Regional Health Service Agency), Aifa (Italian Drug Agency ), NAS (anti-complexity carabinieri) and scientific societies. “Recognizing the need to carefully monitor and monitor the situation. A new ministerial circular aimed at unifying and coordinating control and public health measures on the national territory is being defined,” Andrea Costa, Under-Secretary of the Ministry of Health, explained, responding in the Social Affairs Committee to a parliamentary question submitted by M5S.

Subsequently, the European Center for Disease Prevention and Control drafted a reporting protocol “to report national data from all countries and regions in the European region of the World Health Organization, including the 27 countries of the European Union (EU). The other three countries are in the European Union Economic Zone (SEE). ), at the European level.

According to the World Health Organization, parents should pay attention to the symptoms of hepatitis, which are the acute appearance of diarrhea, vomiting, abdominal pain and jaundice, in which the color of the skin and whites of the eyes turn yellow, while the color of the skin and whites of the eyes turn yellow. You don’t have a fever.” To prevent children from getting sick, it is important to “take regular measures that help protect against common viruses,” such as hand washing and respiratory hygiene.

Leave a Comment