Not just genes or molecular targets, to be targeted with targeted anti-cancer therapies. Today’s exact oncology goes far beyond this horizon, to include a much broader universe. Indeed, cancer prevention has become personal thanks to the identification of subtle molecular modifications that make it possible to identify populations at risk. And in therapies, the paradigm to follow is the mutational paradigm, where all changes experienced by the organism, as a result of changes in the individual and external environment, which may have a role in the development of cancer and in the choice of treatment, must be taken into account.
The new frontiers were defined today at the University of La Sapienza at the “Regional Meeting of the World Health Summit – Europe”, at the session devoted to precision oncology, moderated by Paolo Marchetti (Professor of Oncology at the University of La Sapienza and Head of the Foundation for Personal Diagnostics. Medicine) and Khay-Guan Yeoh (Professor of Medicine, University of Singapore).
“Prevention becomes personal because it can be based on precision medicine models, by identifying specific genomic determinants associated with increased cancer risk – says Marchetti -. This includes a series of interventions to identify the tumor at an early stage or to avoid the onset of the disease. For example, Women with a mutation in the BRCA gene, which is a risk factor for breast cancer, may be offered more frequent breast screening programmes, which are part of secondary prevention, or treatment with aromatase inhibitors or anti-estrogens, which are still in clinical trials, to enhance primary prevention. .so that we can save more lives and ensure savings for the health system.”
Today, experts have concluded that the new model is the ‘mutational’ model in which all changes an organism goes through must be taken into account, including also the microorganisms, the group of billions of microorganisms that live in the body and provide basic support for our life. .
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