Is the fourth dose of the vaccine required? The debate is open – Corriere.it

From silvia turin

There is a debate on the basis of recent studies that Covid can also “hack” vaccines based on Omicron (version BA.1). Pharmaceutical companies pay for licenses first, but governments don’t know if they will continue with currently used vaccines

Governments collect data to assess how Autumn campaign against covid: the fourth dose of all? Fourth dose with updated vaccines?

Omicron does not protect against Omicron

Regarding the last point in particular, the The discussion is in full swing. Those who question the advisability of choosing new versions rely on the belief that increasing vaccinations on Omicron may not give the desired results. effectiveness The fourth updated dose What he would expect in the fall (and this, in fact, would be a new vaccine, such as the annual influenza vaccination) counteracts the ability in which the variant has been shown to avoid antibodies: so to speak, Omicron does not protect against Omicronsince the ability to re-infect the virus in its current form is greatly increased and the result is, for example, eating BA.1 virus does not protect against infection with BA.5, etc..

act fast?

This was clarified by a recent article that appeared in temper nature
, which carefully examines the immunodominance of Omicron sub-variants BA.2.12.1 (prevalent in the United States) and BA.4/5 (which caused the recent summer wave in Europe and Italy) against previous infections of the original Omicron strain, known as BA.1 . The research (and it is not the only one with similar results) raises concerns about the efficacy (again with regard to infection) of the specific vaccine withdrawal effect against Omicron, which was precisely engineered on the primary BA.1 strain. In this regard, the pharmaceutical company Pfizer, which is conducting analyzes on its updated vaccine, urges regulators, through the mouth of President Ugur Sahin, to expedite the issuance of permits: financial times Shaheen says the safety data will not differ from the original vaccine evidence because it will simply ‘Altered a number of amino acids in Spike ProteinThe selection of the new strain (the “fastest” mRNA vaccines to update) took three months, and clinical trials could take another four months.

Vaccines work

But if pharmaceutical companies use tight deadlines and virus variants that track each other as a tool to get the fast track to approval, the same arguments cause concern for scientists, who are holding back. It pays for cost and resource expenditure to upgrade Vaccine may be born ‘actually old’? While the bad news is that the virus may be faster than vaccines updating, the good news is that although the virus is “far off”, vaccines as “old” as those based on the Wuhan strain (currently in use) are proving to be Still strongly protective against the risk of severe disease and this also applies to recent sub-variants of Omicron. Vaccines work great for what they were designed for (save us) and in that sense, and maybe even better, Updated vaccines will work, too. The virus, however, You will continue to get hurtBecause it develops in this way and we are destined to coexist for a long time.

Who recommends the fourth dose?

Vaccination assessment for all, another point on the agenda, is in progress: to balance costs and benefits, the fourth dose should be provided Big difference for most people.
The other thing is to protect them better and better The elderly and the most vulnerable: For them, it makes sense to stimulate the immune system response (which in their case may be struggling to react) and it’s good to do it with the fourth dose and do it quickly and useful so that they continue to be protected. for anyone else, Global organizers will meet later this month To discuss whether to transition to new vaccines designed for the Omicron variant or continue with existing vaccines.

Jun 22 2022 (change on Jun 22 2022 | 14:11)

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