Dengue and Zika manipulate the skin microbiome of their hosts in order to enhance production of acetophenone, which stimulates mosquito bites, and ultimately the spread of viral infections.
Viruses transmitted by mosquito bites It is capable of altering an organism’s microbiome that infect in order to make it produce a Especially attractive scent Insects responsible for spreading the infection. This was revealed by a study just published in Cell, conducted by scientists from the University of Connecticut, Tsinghua University in Beijing, Shenzhen Institute of Infectious Diseases, Ruili Hospital of Chinese Medicine, Dai Medicine and the Yunnan Tropical Diseases Laboratory. Subtropical Animal Viruses and the Chinese Center for Disease Control and Prevention.
A study on dengue fever and Zika
The research was conducted on dengue and Zika viruses and was conducted on specially infected or healthy mice (as a control group). The insects were more attracted to mice that had viruses in their bodies. The authors of the research report that these pathogens have developed a way to increase the likelihood of infecting more individuals. After examining the molecules found in the skin of infected animals, the scientists identifiedacetophenoneproduced by Bacillus bacteria that reproduce on the dermis of humans and mice, as one of the Stronger calls for mosquitoes. Sick rodents exuded about 10 times more acetophenone than their uninfected counterparts. The researchers also found that human dengue patients emit more of the molecule than healthy people. “The virus can manipulate the host’s cutaneous microbiome – explains Bengua Wang, an immunologist at the University of Connecticut – in order to favor the production of acetophenone, which stimulates mosquito bites, and ultimately the spread of infection.”
Smells of sickness
Anyone can age a Different body odor when sickEspecially with infection. Covid patients, for example, release a distinctive mixture of molecules that dogs and electronic “nose” can detect. Malaria parasites also alter the scent of the human host, and trained dogs can smell spikes in insulin in people with diabetes.
Antidote to keep mosquitoes away
The benefit of this discovery comes from the possibility of odor blocking at a chemical level to discourage mosquitoes and thus reduce the risk of transmission. In particular, scientists in this case evaluated the effectiveness of one of the derivatives of vitamin A, isotretinoin: Gravity appears to be reduced in animals treated with this product for mosquitoes. “For the next steps – the authors conclude – we will continue to explore this compound also in human patients, in order to investigate whether altering skin odor and microbiome can reduce the risk of infection and transmission of Zika and dengue virus.” A new way to combat these diseases is by reducing the invitation of mosquitoes.
Dengue fever and Zika around the world
Dengue fever, transmitted by mosquitoes in tropical and sometimes subtropical regions, causes fever, rash, pain, and, in more severe cases, bleeding and death. Zika virus from the same family causes a severely symptomatic viral disease and is also transmitted by mosquitoes.
In Italy, dozens of dengue cases are reported each year, but they are generally infections caught abroad (see article on this topic) over here
Jul 2, 2022 (change 2 Jul 2022 | 19:00)
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