Alzheimer’s disease: Scientists have discovered how the brain “fries” by causing brain cells to overheat

A research team has found a link between the development of heat within cells and the accumulation of proteins, a crucial phenomenon in the degeneration of a disease such as Alzheimer’s. This discovery opens new avenues in the study of the disease.

A new study focusing on intracellular temperature in the brain has given major advances Alzheimer’s disease research.

Some diseases are too complex to study, making it difficult if not impossible to identify possible causes and treatments. Alzheimer’s disease is one of them: unfortunately, research cannot benefit from sample collection as long as the patient is alive. For this reason, we are always looking for a new way to identify this neurodegenerative disease even if the patient is asymptomatic.

With this recent study, an attempt was made to circumvent the sample collection problem by exploiting the similarity between zimmers and some cases of metastases, given the similarity between the appearance of these two diseases and the recognition in both the presence of an increase in cells. the heat. The team of researchers and researchers note that this increase in temperature may be related to stress at the cellular level.

To understand how high temperature is linked to the development of Alzheimer’s disease, it is helpful to understand what happens in the brains of those who suffer from the disease. Simply put, there are two types of proteins – tau and beta-amyloid – that form abnormal copies of themselves. From here, fibers are formed that assemble and cause the death of brain cells. Notorious results

  • memory loss
  • character change
  • Difficulty completing daily activities.

Thanks to the use of thermometers capable of recording even the slightest changes, it has been observed that when fibers coalesce, there is heat generationi.e. an increase in temperature due to the accumulation of proteins.

Alzheimer's disease: Scientists have figured out how

© J. Am. Chem. 2022, 144, 22, 10034-10041

The relationship between temperature increase and protein accumulation was simplified with a metaphor accessible to all by Dr. Cheryl Kaminsky, who led the study:

Overheating a cell is like frying an egg – as its temperature rises, the proteins begin to clump together and become nonfunctional. The assembly of beta-amyloid requires a lot of energy to start, but once it starts, the process is accelerated by releasing more and more heat, further enhancing the assembly.

By studying this reaction in the lab, the team was able to test a new drug that could fight Alzheimer’s disease. MJ040 prevents the accumulation of beta-amyloid and thus directly combats the degeneration of the disease. This discovery helped the scientific community establish a clearer relationship between fibrillation and thermogenesis, and opened up exciting new avenues for researchers.

However, MJ040 remains a drug that can only be given when Alzheimer’s disease is already active and therefore cannot be prevented, only treated. Add to that the fact that it will take a lot of lab testing before it can be marketed for wider use.

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