Discover the mechanism that can cure it

American scientists claim to have discovered a genetic inducer of hair growth, which appears to be able to cure baldness.

Eugenio Spagnolo

Problems baldness? A few more years and it might just be a memory. A group of American scientists discovered the main ingredient that stimulates hair growth in men and women. It’s a protein, SCUBE3, which It can finally eliminate baldness and hair loss such as alopecia. But how does it work?

Farewell to baldness and alopecia: the discovery

The assumption from which researchers at the University of California, Irvine started, is that dermal papilla cells are responsible for the growth of new hair. To be precise, these are the specialized fibroblasts located at the bottom of each hair follicle. Although scientists already knew that these cells contribute to hair growth, they did not yet have a clear picture of how this occurs from a genetic point of view. “During the life cycle of a hair follicle, dermal papilla cells can send signals that keep the follicles dormant or stimulate new hair growth,” comments Maxim Plikus, professor of cell biology and evolution at UCI. SCUBE3 molecule, which is naturally produced by dermal papilla cellsis exactly the messenger used to say Hair stem cells begin to divide: a mechanism that heralds the initiation of new hair growth.”

In short, Activation of SCUBE3 by dermal papilla cells is the essential step for initiating hair growth. This is confirmed by the fact that in conditions such as androgenetic alopecia, the cells of the dermal papilla do not function properly. This reduces the amount of available activating molecules.

I study

In their study, the researchers used lab mice with hyperactive dermal papilla cells to examine this process. “This model allowed us to identify SCUBE3 as a previously unknown signaling protein that can drive abundant hair growth,” notes study co-author Yingzi Liu, a UCI postdoctoral researcher in cell biology. In the experiments, the team injected SCUBE3 into the skin of mice that had transplanted human scalp follicles. The molecule causes new hair to grow In both human and surrounding hair follicles. “These experiments provide evidence of the principle that SCUBE3 or its derivative molecules may be a promising treatment for hair loss,” the researchers excited.

If the study continues as expected until human experimentation and scientists get all the necessary assurances, Within a few years, innovative drugs can reach the market that stimulate the SCUBE3 activation mechanism and thus hair growth. “There is an urgent need for new, effective hair loss medications and natural compounds used by dermal papillae cells are usually ideal candidates for next-generation therapy,” concludes Dr. Plekus. Which in the meantime has already filed a patent application on Scube3 and its future uses…



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