Study Sapienza University of Rome

you smokeyou suffer from high pressure And the are you married.? coverage Serum lasts less The survey comes from a new study conducted byUniversity of La Sapienza And from Umberto I Clinic From Rome, which identified demographic, clinical and social factors that interfere with the immune response after Covid-19 vaccination. The results were published in the Journal of Personalized Medicine and, in fact, paved the way for customizable vaccination programmes.

There are those who receive greater and longer-lasting coverage from the Covid vaccine, and those who do not. it depends on what? From health status and lifestyle: In fact, there are several variables that can affect the ability of individuals to acquire this immunity.

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The study saw the participation of two health workers from the University Hospital: a sample of 2,065 health workers from Policlinico Umberto I, who were given a Covid-19 vaccine with Pfizer BioNTech mRna, were actually exposed to two blood samples. . The first is after a month and the second is 5 months after the second vaccination. “All participants – explains Stefania Basile, study coordinator – were given a questionnaire to collect personal information and a quantitative serological test was performed to detect antibody to S protein (spike) from Sars-CoV2 virus. The best tool for coronavirus. Assessment of acquired immunity after vaccination or infection ” .

‘Significant’ drop in antibody levels

The results showed that one month after vaccination, people with previous and younger Covid-19 infections had higher levels of antibodies compared to other people in the sample considered. In contrast, autoimmune diseases, chronic lung disease, and smoking are associated with lower levels of antibody responses. Five months after vaccination, an average decrease of 72% in the level of antibodies is observed, but this is less pronounced in women and in people with previous infections. On the other hand, a significant decrease in the levels of Spike antibody was found in smokers, people with high blood pressure and the least young by about 82%.

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Also among the research authors is Sapienza Director Antonella Polimeni, who stated that “the study highlights how the pursuit of health, even in the face of epidemic situations, underlies a more general principle of social well-being. Indeed, lifestyle factors play an important role in the immune response. The first treatment, then, is to raise the health culture and quality of life.”

Antibodies are suitable for individuals, and less so for married people

The investigators also revealed greater retention of antibody responses in unmarried or cohabiting individuals than in married, divorced or widowed individuals, although this association may be due to other unexplored clinical variables, such as eating habits and body mass index.

“Although our study confirmed many of the already known associations, it also took into account for the first time – as coordinator Stefania Basile concludes – many factors including education level, type of work, marital status and burden of participation. Our analysis requires further research to investigate the effects of sex- and lifestyle-related variables on the immune response, and to produce personalized and precise medicine.”


Last update: Friday, July 8, 2022, at 16:34

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